there is something called the hallmarks of cancer these are six things proposed by hanahan and weinberg there are six hallmarks of cancer like invasion invasion basement membrane poor immune surveillance angiogenesis one of the ones you mentioned these are sort of six biological hallmarks of cancer and that is a highly influential paper and it's been really extremely well cited and has shaped a lot of people thinking it might be one of the most cited papers in oncology i think it might be i think you're right it might be in fact the most cited paper in oncology