Loss of P10, amplification of MYC, and loss of P53 are genetic alterations associated with the transition of localized prostate cancer to a lethal form.

“the general genetic trait associated with that transition from localized to localized with lethal potential is an is something to do with the P10 akt pathway okay and that doesn't mean that you have a lethal tumor if you have P10 loss but it in my mind it begins to open up the book to say lots of other mischief and nonsense can go on within the tumor we know from lots of studies that if you have loss of p-53 for example course that that's associated with lethal prostate cancer amplification of Mick lethal cancer in general yes exactly amplification of Mick is another one too it's the emper so it's interesting so basically between Mick and p p uh P 53 and all of K I mean I'm sure K is associated less so K but yes those are classic”