Chloroquine, a lysosomal inhibitor, can cause toxic effects by damaging lysosomal membranes and liberating lysosomal contents into the cytosol, which may contribute to its anti-cancer effects.

“Well, it's not exactly [inaudible] or chloroquine is a lysosomal inhibitor. It's a molecule that, due to its charge, will specifically enrich in the membranes of lysosomes, and then causes lysosomal membrane damage, potentially also inhibition of autophagy. But it fundamentally also liberates the potentially toxic content of lysosomes into the cytosolic space.”