The number of mutations in cancer increases with the number of cancer cells.

“we we have a pretty good sense that the more cancer cells a person has in their body the more mutation they have right so the difference between a billion cells I.E one cc of cancer versus a trillion cells right which is like an almost fatal load of cancer is an enormous number of mutations and therefore it's not only bad from the mass effect but also from now the fitness of it right you have so you just have such a genetically um a bad genetically diverse population so you have enormous heterogeneity within the genetic um you know Badness for lack of a smarter word”