Oncogenes upregulate fermentation pathways to compensate for reduced energy from damaged oxidative phosphorylation.

“now because the oncogenes are transcription factors that up regulate fermentation pathways so basically you when you damage the respiratory system of a cell if one alpha becomes stabilized and now you can up regulate glucose transporters into the cell glutamic is a glutamine they're all overlap each other lactic acid dehydrogenase you know all these enzymes that are geared for maintaining a fermentation metabolism the transcription factors that make those pathways up regulated are the oncogenes basically”