Incubating cancer cells in vivo with mutation-inducing chemotherapy drugs, after pinning them down with another effective therapy, may increase mutations and trigger immune recognition, enhancing the effectiveness of therapies like PD-1 antibody treatment.

“basically you can incubate cancer cells and by incubate I mean actually in in a living being um with mutation inducing drugs AKA chemotherapy drugs certain chemotherapy drugs um but to for that to work you need to actually be you have to kind of pin them down with another therapy first right so some of the therapies we've talked about already that like actually are effective um you know partially effective for a period of time you know months to many months in some cases before resistance might manifest to some of these targeted therapy approaches if you pin them down with that therapy and incubate in you know these chemotherapy drugs that basically start to dial in more and more mutations um at least in Mouse models um it would appear that actually you can you can buy the time that you need to be able to actually introduce new mutations and have that um trigger immune recognition and make even you know pd1 antibody based therapy you know much much more effective effective”