Targeting uncontrolled nucleic acid synthesis in cancer cells with medications like pemetrexed can induce mutations that enhance immunotherapy effectiveness.

“you know the most fundamental of these is the fact that in order to do the uncontrolled growth they have to do uncontrolled nucleic acid synthesis and this is the vulnerability that was targeted initially by farber but has been targeted by a lot of very important medications that are you know widely used still today you know pematrex is first-line treatment for lung cancer and if you get these medications right you can induce mutations through you know the metabolic stress on the nucleotide system and this can make immunotherapy work better”