the most stunning finding of recent years in my view in this field is that virtually every patient recognizes a unique antigen and so we're in the process of writing a paper now on 195 consecutive patients that we've identified the exact antigenic nature of what the t- cell can recognize and it can recognize in about 80% of all histologies and that turned out to be 363 individual antigens that were recognized in these 195 patients and no two patients shared the exact same antigen with the exception of two patients that had a Kass mutation that was recognized on a very rare class one molecule c802 HLA molecule