Peter Attia· MD
so there are inhibitors of RAF MEK and ERK which are downstream of rafts and those are actively in use in the clinic but they seem to be not durably effective in raster oven cancers because of the workarounds
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so there are inhibitors of RAF MEK and ERK which are downstream of rafts and those are actively in use in the clinic but they seem to be not durably effective in raster oven cancers because of the workarounds
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
I think too many work arounds is the common problem
Whole-body MRI screening in healthy adults produces more incidentaloma harm than cancer-mortality benefit.
Starting colonoscopy screening at 45 (vs 50) prevents enough early-onset cancers to justify the population cost.
Multi-cancer liquid-biopsy tests like Galleri detect early cancers at a stage that meaningfully improves survival.