T-cells selected for mutation reactivity and administered after temporary elimination of the patient's natural immune system resulted in a disease-free state for a patient with bile duct cancer, with disease-free survival for eight years.

“developed techniques that enabled us to develop te- cells specifically targeting mutations and published the first paper on that in 2014 it was a patient with a bile duct cancer cango carcinoma that uh was widespread in the lungs and liver we gave her we gave her bulk till cells did not work those were till that were not genetically modified those were you I those were not Gene those were the N so our work went in two directions genetically modifying till or figuring out ways to use natural till and these were natural till that uh was selected for mutation reactivity and given to a patient and whose natural immune system was temporarily eliminated and she's living disease free now eight years later all of her liver and lung disease is uh is gone”