what's interesting is that the pediatric oncologists learned this a long time ago this is how they cure leukemia um they give an induction therapy and then they immediately change to a different therapies so what they learned was that even after induction therapy when there was no apparent tumor in the bone marrow or in the blood that if you didn't do anything the kids would all relapse and so they hit it immediately with another with another group of drugs and then another group of drugs they they it and so this is you know first strike second strike kind of approaches