so macrophages cells of our immune system are extremely extremely few so genic okay they do this doomed healing like you'll see multinucleated giant cells and a lot of parts of our bodies during wound healing and this kind of thing and cancer cells you also find a lot of these multinucleated kinds of cells so our body recognizes wounding as an acute problem and the immune system will come into that local area to facilitate wound healing and when the wound persists sometimes these cells will fuse with each other and fuse with other cells in the micro environment to facilitate wound healing the problem is is if you have an epithelial cell like a breast cell or a colon cell that is coming and becoming neoplastic becoming dysmorphic and its growth regulatory and it's fermenting but it doesn't have the capacity to grow anywhere outside of that local area it doesn't have have the capacity so our immune cells come into this lesion if you will that's persisting the immune cell throws out growth factors and cytokines to facilitate the wound to facilitate wound healing the problem is those factors are also facilitating the growth of the neoplastic cell