Whole brain radiation use has decreased by approximately 90% over the last 20-30 years, with a shift towards focused treatments to minimize side effects.

“wholeb brain radiation is probably to give you a number it's I don't know what the absolute number is but it's probably 10% of what it was 20 30 years ago the original studies out of Kentucky that Patel had done in neurosurgery everyone used to get wholeb brain radiation following uh either following resection of the metastasis or even if it was unresectable and there was some good data back then supporting that but nowadays rather than whole brain you're usually going to do a focus treatment just to a smaller area and this is kind of a you know a universal trend to less radiation dose to a smaller volume”