Prophylactic cranial irradiation (PCI) with 20 gray in five fractions is a standard treatment for small cell lung cancer with complete response in the thorax, reducing CNS failures by 70-80% and improving quality of life.

“small cell lung cancer part of their uh regimen is going to be once the primary has been treated if they have a complete response in the thorax prophylactic cranial radiation only for small cell PCI 20 gray five fractions been done forever shows an advantage they have lower low lower uh a reduction in CNS it's a lot i think it's probably 70 80% reduction in in CNS failures because they all fail there otherwise that little small cell they just all do that and at 20 gray they really don't have too many side effects but again of course the caveat is always small cell you know extensive stage small cell lung patient isn't going to have a long-term survival but at least they won't fail in the brain it's a quality of life issue”