Rhonda Patrick· PhD
Yeah, so, there's been a lot of talk about concurrent training being detrimental, there was something called the chronic interference hypothesis, which, basically, was actually shown in animal models, in rodent models where the intracellular signaling for cardiovascular exercise upregulated your catabolic pathways, your AMPK pathway. Again, I don't want to get too technical here but the AMPK is a catabolic pathway which actually blunts the mTOR pathway, which is an anabolic pathway. Alternatively, your resistance, your anaerobic exercise was your anabolic pathway, thus, if you did aerobic training, it would blunt the adaptations for resistance training. And that actually has been shown to be at least, at the very least, a way...oversimplification. Now, at some point, there will seem to be some interference but it does seem that that point is a lot further along than what we originally had thought. And I think that more has to do with the overtraining effects than probably the intracellular signaling effect, so, it's not clear. But we have some pretty good meta-analytic data now showing that, within, you know, decent volumes of training, there does not seem to be a blunting of the anabolic effect, and that's even when it's performed in the same day.