Peter Attia· MD
if those um apob wrapped lipoproteins get trapped inside the endothelial layer a chemical process known as oxidation takes place and that leads to inflammation what that means is the body thinks something is wrong and I need to fight it just as when you get an infection a healthy immune system detects the inflammation caused by the microbial agent and it sends the troops there to get rid of it but in this case the insult does not come from an infection it comes from the oxidation of the cholesterol contained within the apob particle as it sits in the endothelium and that process initiates a devastating Cascade of events that ultimately can create so much damage in the wall of the artery that it can lead to a rupture of the plaque which is the repairing process the rupture of that plaque acutely leads to blood loss and ultimately oxygen loss to the muscles of the heart beyond the point of that blockage that process is known as a heart attack