A high linoleic acid diet increases oxidative stress and decreases nitric oxide metabolism, leading to endothelial dysfunction.

“urinary excretion of eight iso prostaglandin f2 also known as eight isoprostate increased after the linoleic acid diet this urinary prostaglandin eight iso pgf2 alpha is known to be associated with oxidative stress and increased in atheromas and in people that have oxidized ldl and the urinary concentration of nitric oxide metabolites these are the metabolites that are important for vasodilation and healthy endothelial function decreased in the linolenic acid group”