The scientific literature treats the association between TMAO and cardiovascular/kidney disease as fact, despite not substantiating a causal link.

“that association that is an association only that is not causal”

“the fact you cannot draw causative inference from observational studies we should not be doing that but all of the tmao literature does that”

“if you hear someone say tmao causes problems in humans whether it's heart disease stroke diabetes or kidney disease turn your ass around and walk the other direction because they do not know what they're talking about”

“in 98 of the literature i can find that is treated as if it is fact as if it is canon as if it is a truism and that is very frustrating to me when the majority of the literature will not substantiate that causal link between tmao and any of those things”

“tmao is not harmful for humans guys uh it is reverse causality is the fact that it's associated with increased cardiovascular disease because in kidney disease or an insulin resistance tmao goes up so it looks like tmao is bad because it's consistently associated with more cardiovascular disease but there's zero good evidence in humans the tmao is directly causal”