Patients with Dunnigan type familial partial lipodystrophy have visceral adipose tissue and atherosclerosis despite not having elevated LDL.

“when you get fat adipose cells when you get fat adipocytes when you get hypertrophic adipocytes they leak free fatty acids and that leads to what that leads to metabolic dysfunction and what does metabolic dysfunction lead to atherosclerosis”

“this is actually dunigan type familial partial lipodystrophy what's interesting about this is it's also one gene that has really nothing to do with the ldl receptor these people have quote normal levels of ldl and they have premature atherosclerosis so this is one of the things where it doesn't really seem very consistent if we're thinking about monogenic diseases or mendelian randomizations these are people who have premature atherosclerosis with one mutation in the gene it's the lmna gene”

“dunnigan lip type familial partial lipodystrophy patients do not have elevated ldl but they have horrible insulin resistance they're full of visceral adipose tissue and they get atherosclerosis very quickly”

“familial partial lipodystrophy dunnigan type with a single gene mutation that causes premature atherosclerosis is fascinating”