Paul Saladino· MD
across people with familial hypercholesterolemia a genetic predisposition to high levels of LDL there is no clear correlation between levels of LDL and heart disease incidents
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
across people with familial hypercholesterolemia a genetic predisposition to high levels of LDL there is no clear correlation between levels of LDL and heart disease incidents
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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and as I will show in a moment not all people with quote unquote familial hypercholesterolemia develop premature aerosis but in many people with certain Snips single nucleotide polymorphisms that affect cholesterol metabolism uh their monocytes their immune cells are not quote unquote normal
but even in those groups 70% women and 50% of men will not develop premature heart disease