Short exposures to high blood sugar levels can alter gene expression in cells, suggesting a mechanism for diabetes complications.

“it still puts it just like nature to with us like that I mean you have to deal with some epigenetic change in response to a glucose but man it's so unfair but in the end it shows you that we had a very superficial understanding of diabetes complications years ago and again now there's a whole rich field that's devoted to this idea of these windows of hyperglycemia permanently altering these important cells that ultimately contribute to diabetes complications”