A 5-8 mmHg drop in systolic blood pressure and a 3-5 mmHg drop in diastolic blood pressure is considered clinically significant and associated with reduced cardiovascular events.

“do we think that that's clinically significant so if those men yeah no that's clinically significant for sure i mean uh when when blood pressure goes up that much um that is definitely associated with increased cardiovascular events over time um and so um it's thought to be clinically significant when you can lower diastolic by more than like three millimeters and when you can lower your systolic by like more than four or five millimeters”