Modern statistical analysis of the Minnesota Coronary Experiment found no difference in cardiac events between polyunsaturated fats and other fats, contradicting the original analysis.

“Ramden went and published all of these data plus a whole bunch of subdata as I said just a few years ago I believe in the British medical journal and actually found something that was that threw a wrench in my initial hypothesis my initial view of the Minnesota coronary experiment was it probably wasn't a long enough intervention it might be that 5 years was not long enough to appreciate a difference and so it was underpowered or Too Short in a duration to see a benefit if there was a benefit but in Ramon's analysis you actually saw the opposite because he now looked at some subgroups and you actually saw a higher incidence of coronary events in some of the people that were consuming the high polyunsaturated fat diet”

“the experiment that completed in I think it ran I I can't remember exactly think it ran about 5 years in 1973 showed no difference there was no difference in cardiac events despite the fact that the group that was on the higher polyunsaturated fat group did indeed have much lower cholesterol levels”

“directionally I believe that the higher Pua group relative to the saturated fat group was about 30 mg per decil lower in total cholesterol and based on everything we know today we would assume that much of that was in LDL cholesterol indeed being lower and non-hdl cholesterol and yet there was no difference in events”

“showed no difference there was no difference in cardiac events despite the fact that the group that was on the higher polyunsaturated fat group did indeed have much lower cholesterol levels”

“the the the one study that will they'll site is the Minnesota coronary experiment and there's a there's there was some strength to that experiment it was uh they provided all the meals to participants and they did either you know they were controlling their their intake either High polyunsaturated fat diet or high saturated fat diet and it was a randomized control trial for several years where they're looking at outcomes uh like heart attacks and whatnot which is great here's the downsides when they analyze that data with more modern statistics they found that I mean really the there was no difference”