Atherosclerosis in large arteries like the abdominal aorta may take a long time to cause significant issues such as an aneurysm, whereas blockages in smaller coronary or cerebral arteries can rapidly impair blood flow due to their narrow lumen.

“you can get atheroslerosis in your big abdominal aorta but that takes an awful long time before it's going to basically get to the point where you have an aneurysm and explodes but the coronary disease of the cerebral arteries uh because their Lumen is so small and you know the Lumen of a coronary artery is like the dot of a pencil that's so it doesn't take much to afflict the affect the blood flow that's going through it”