Lp(a) is associated with initiating and progressing atherosclerosis and endothelial dysfunction.

“absolutely uh i think it's actually both so the macrophages of patients with high lpa are already activated and they will get uh as soon as there's and some endothelial dysfunction they'll get there they might even cause endothelial dysfunction so lpa is is is associated it's probably a main driver before the onset of any discernible plaque but it also has this double whammy where it's it initiates the disease but it also is associated with the progression uh with the progression of the of the of the disease”