Paul Saladino· MD
so below the endothelium is the intimal space which is where macrofagos tend to engulf LDL particles that's felt to be canonically the beginning of an atherosclerotic plaque
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so below the endothelium is the intimal space which is where macrofagos tend to engulf LDL particles that's felt to be canonically the beginning of an atherosclerotic plaque
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the present lipid hypothesis posits that these LDL particles they're getting uh into the subintimal space and that by that I mean into the vasculature into uh underneath the endothelial cells and they are getting trapped in these things called proteoglycans kind of think of you know stocks if you will and when they get trapped they can get modified and that's when these macroasia come to gobble them up what they're supposed to do is they're supposed to anything that's there any kind of pathogen they're supposed to take it and then go away and the present lipid hypothesis is that they often get come to an oxidized LDL particle and they get stuck they consume it they get stuck Etc