Cholesterol within very low-density lipoprotein (VLDL) particles is atherogenic, and a high number of these particles increases cardiovascular risk.

“all you're identifying there is you have increased cholesterol content in VLDL particles and because the ones we fear the most are remnants we're just presuming oh boy there's got to be remnants here”

“what's atherogenic is the cholesterol inside the vldl particles it's the number of those particles that get into the wall”

“the vldl cholesterol because the cholesterol that's in the very low density lipoprotein particles the particles that come out of the liver that cholesterol is atherogenic there's a lot of triglyceride in that particle so the people who measure triglycerides say well the triglycerides are high that must be the problem and there's no question that people with high triglycerides are at increased risk of heart disease but the people with the high triglycerides were at increased risk of heart disease have a higher number of LDL particles and vldl particles it's the particle”