Apolipoprotein E (ApoE) function is complex due to its ability to change shape and lipid-binding affinities, with its N-terminus typically binding to receptors and its C-terminus interacting with the lipid core.

“apoe is a bit more complicated than the rest of the lipoproteins because it can take many shapes and forms and the affinities can change based on lipid binding it has two arms an n terminus a c-terminus typically the n-terminus binds to the receptor and the c-terminus is buried inside the lipid core of a lipoprotein particle”