Peter Attia· MD
we were really struck with how different individuals hdls were at their ability to extract cholesterol from cells even with the same HDL cholesterol level
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
we were really struck with how different individuals hdls were at their ability to extract cholesterol from cells even with the same HDL cholesterol level
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
it's sort of affirmed this concept that HDL cholesterol is not really telling us or informing us on the efficiency of the function of HDL at least in this case the function define mind as the ability to extract cholesterol from cells
developed what I'll call an anex Vivo cholesterol reflux assay where the concept is we took someone's blood or plasma we isolated the HDL specifically we got rid of the apob contained lipoproteins and then put that on cells that were labeled with cholesterol and we measured the effectiveness by which that HDL removed cholesterol from cells