Peter Attia· MD
a genetic model was at least some people with certain CETP variants had very high HDL cholesterol and they didn't seem to get much heart disease
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
a genetic model was at least some people with certain CETP variants had very high HDL cholesterol and they didn't seem to get much heart disease
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we know this because people who lack CTP have hugely elevated HDL cholesterol levels big time like over a hundred
we know that if ctep is inhibited this enzyme is inhibited HDL cholesterol goes up
and that only happens if you almost completely knock out CTP so you have to really inhibit it by about 90 percent which is very close to the homozygous patients in Japan they also have half LDL and about a triple HDL