Paul Saladino· MD
LDL will go down if you decrease saturated fat and increase PUFA but in this study oxidized LDL went up LP little-a went up
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
LDL will go down if you decrease saturated fat and increase PUFA but in this study oxidized LDL went up LP little-a went up
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they took the saturated fat which is supposed to be killing us they decreased it from 28 to 20 grams and they increase the amount of heart-healthy quote-unquote polyunsaturated fat that your that your cardiologist would love from 11 to 19 and they saw what happened to the ldl well guess what the amount of oxidized ldl in the plasma increased and the amount of lp little a increased despite the fact that overall ldl levels went down
basically what happened in this trial this is an Interventional trial 37 women were fed two diets and one diet was low in vegetables the other was high in vegetables okay and there was a diet that had a saturated fat intake decreased from 28 to 20 grams a day um and a polyunsaturated fat that was increased from 11 to 13 and uh to 19 excuse me so they they increased polyunsaturated fat from 11 to 13 grams to 19 grams so they increased polyes to about by about 10 grams a day and they decreased saturated fat by only about 10 grams a day and one group was high in vegetables and one group was low in vegetables and lo
There's a really interesting article have you seen this one so check this one out have you seen this article changes in dietary fat intake alter plasma levels of oxidized low density Li protein and LP little a
if you take people and you decrease their saturated fat and you increase the polyun tetrative fat what happens this is where things get really interesting LDL goes down apob goes down and the mainstream Physicians put their hands up and they get so excited and they ignore the fact that oxidized LDL goes up and that LP little a which is a scavenger molecule like LDL that holds on to oxidized phospholipids that goes up
a lowering of the LDL with increased polyunsaturated plant fats is also accompanied by an increase in oxidized LDL and LP ltil A lipoprotein ltil a and those are strong risk factors for an increase in cardiovascular disease risk