Inhibiting CETP theoretically increases HDL cholesterol by preventing cholesterol transfer from HDL to ApoB particles.

“what is one of the genetic conditions that would give you high HDL cholesterol I remember I just taught you what April D is CT t PC tip it takes the cholesterol out of your HDL and gives it to an April B particle so theoretically that would lower your HDL cholesterol but if I inhibited C tip your HDL would get to keep all its cholesterol what would go through the roof your HDL cholesterol”

“this so-called cetp cholesterol transfer protein essentially transfers cholesterol Esters between April B containing lipoproteins in HDL and it's a major modifier of the HDL particle in terms of its size and composition”

“it wasn't long until companies drug companies were saying hey wait a minute we know that if ctep is inhibited this enzyme is inhibited HDL cholesterol goes up that must be a good thing right that led directly from this observation I mentioned that people who lack CTP genetically have these hugely elevated levels of HDL one directly from the other well gosh that must mean that if we could pharmacologically inhibit CTP it would be a way to raise HDL”