Peter Attia· MD
If you knock out one of the anticoagulants, so knock out, say, protein C, protein S, any of the anticoagulant, the mouse won't make it through half of the embryonic, basically day seven or day eight, they die.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
If you knock out one of the anticoagulants, so knock out, say, protein C, protein S, any of the anticoagulant, the mouse won't make it through half of the embryonic, basically day seven or day eight, they die.
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So if you knock out any of the procoagulant coagulation factors, say any of the one, factor two, prothrombin, you'll get a sick mouse, but the mouse will survive through development. So they will survive. And then what kills them is the process of being born. So they'll die right after birth. If you knock out one of the anticoagulants, so knock out, say, protein C, protein S, any of the anticoagulant, the mouse won't make it through half of the embryonic, basically day seven or day eight, they die.