Paul Saladino· MD
they showed that APO B and you know LDL cholesterol even at quote unquote normal levels still had atherosclerosis developing
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they showed that APO B and you know LDL cholesterol even at quote unquote normal levels still had atherosclerosis developing
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without that April B being up there they wouldn't have heart attacks and strokes
in the past we've talked about the importance of knowing the number of particles you have and how that is a more accurate predictor of your atherosclerosis and so the LDL P which is similar to the a PO B in terms of its predictive power which is the number of particles
if they're both high in a given person that person's a terrible risk
if you want to use cholesterol for anything nowadays because let's face it that was the first parameter look dad in the epidemia may certainly correlated total cholesterol levels with the risk for heart disease but think about what I just told you it's the cholesterol within all the lipoproteins what is the if you counted particles what is the most numerous particle in your bloodstream the april-b particles well actually the HDL s are more but they're so small they don't carry much cholesterol so most of your if you want to put a parenthesis around atherogenic cholesterol would be within your april-b particles so if you want to ascribe any use to total cholesterol it's a real poor man's april-b level in general most people with very high total cholesterol levels will have a very high April beat up on there and that's the real reason their risk for atherosclerosis because those are the particles
the only value that calculated or directly measured LDL cholesterol brings to the table is it's a better poor man's estimate of your LDL particle concentration then is total cholesterol