Approximately 2,000 known genetic mutations result in a phenotype of high LDL, high HDL, and low triglycerides, which should be considered in lipid models.

“even if you ignored the first two points I've made which I would argue you can't I'm still unconvinced at this notion that we should exclude the roughly 2,000 genetic mutations that are known to produce a phenotype of high LDL high HDL and low triglyceride these are called natural experiments”