Oligodendrocytes are major cholesterol producers in the brain, synthesizing cholesterol primarily for myelin sheath formation, and do not supply cholesterol to neurons.

“and so obviously has very similar roles and your brain makes its own cholesterol right it's not generated in the periphery and transported across most of it is synthesized in Scituate a so it's synthesized in the brain from precursors such as ketones or glucose they create the backbone and then it has to be moved around so a PO a is mainly made in the astrocytes and maybe in the microglia and then it's it's absorbed or the receptor is on them on the neuron so it's being used to shuttle lipids and cholesterol you know through the brain from where it's synthesized to the neurons which are then gonna use it to you know make their membranes or or you know synthesize precursors”