Paul Saladino· MD
the LDL molecule is necessary but not sufficient for the development of the atherosclerosis
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the LDL molecule is necessary but not sufficient for the development of the atherosclerosis
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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the undertone of everything we've said is not only that apob is causal but that it's a necessary but not sufficient driver of atherosclerosis and i think that's important because necessary but not sufficient creates a lot of confusion in medicine doesn't it right necessary means you have to have an apob particle traffic a lipid into an artery wall if that doesn't happen you don't get atherosclerosis sufficient means if that's the only thing that happens do you necessarily get disease no you don't