The ileum reabsorbs 90-95% of bile salts, limiting their effectiveness for cholesterol depletion unless a drug like bile sequestrants is used to promote excretion.

“our ileum doesn't cooperate our ileum you typically reabsorbs about 90 to 95% of the bile salts and reuses them so it's not the best way unless you can make sure that bile soul is being excreted and we have a drug the bile S&C questions that make sure that happens then you would deplete internal cholesterol”