Patients should demand that their Lp(a) level be known, especially if they have a family history of atherosclerosis.

“if you're listening to this as a patient you should demand that your LP little-a be known it's non-negotiable especially if you have a family history of atherosclerosis”

“and a lot of the times you can see things in family history like you can often spot an elevated LP little-a before you get the Bloods back cuz usually I've done a history and a physical on a patient before I get their first blood test back and it's not uncommon for me to see just a violent streak of heart disease in a family and be like okay you're gonna have an elevated LP little-a there's no two ways about it and sure enough they come back and it's high and you could see that their dad had it their dad's mom had it their dad's mom's mom had it and you just sort of because it's a codominant inherited gene so you can see how it rattled through the family”

“the pattern of inheritance is true autosomal dominant uh pattern of inheritance so uh it's like any uh like for instance if you compare it with a monogenic disorder let's say familial hypercholesterolemia in in quebec we have a very famous mutation which is a 15 kilobase deletion in the ldl receptor so if uh if you inherit that then if you inherit at least one copy you know you'll you'll have fh for lpa if you inherit a genetic variant that's associated with high lpa chances are you'll have ilpa as well because you only need one variant and not necessarily two so you need either the allele from uh your father or your mother that will rise lpa”