We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
well that's a big deal if you're using that as sort of the basis to determine the lipid hypothesis because if it's a compromised physiology you've got to first determine for sure that the what the compromise is is strictly LDL levels
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
yes can we talk a little bit about familial hypocholesterolemia it's a stumbling point or it's a talking point I should say for many of The Advocates of the response to retention hypothesis which is essentially the mainstream Paradigm for LDL geometrically causing atherosclerosis they often point to people with familial hypercholesterolemia and you and I have had some great discussions offline about problems with using FH uh familial hypercholesterolemia as a model for otherwise healthy metabolically healthy individuals with quote unquote elevated LDL so walk us through some of this