The concentration of Lp(a) gene in centenarians does not flatline after age 80, requiring further investigation.

“I wonder if there's a clue to a very vexing question which is why is it that some people with high LP little-a do not go on to get premature heart disease many do most do a significant number do not and it appears completely uncoupled from the level of their LP little-a which makes me wonder are there virulent and non virulent phenotypes that at the level of expression by number or molecular weight aren't captured”

“and in the families where the alpha literally is very elevated but nobody's having any events into their 80s maybe you don't need to be as aggressive”