The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it's a lipoprotein with an AOA attached to it yeah and if you were gonna like come up with an equivalency you'd do like three little like parallel lines as an equal line and say that's equal to LDL - little a or little a PO a would be like the longhand way to write that
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
but it wraps onto a low density lipoprotein and then it becomes kind of a supercharged load low density lipoprotein it becomes a particularly nefarious ldl and we're going to talk about all the reasons why it's not responsive to the same treatments etc
so lpa is the gene that codes for april lipoprotein little a which then binds to an ldl and then turns an ldl from being just a garden variety ldl into an lp little a and i think once people understand that it becomes easier i think for us to communicate in this way
in some people who have the genetic IC Machinery their liver makes another protein called APO protein small case a the guy who discovered it thought he discovered a new antigen a was the signal for antigen so that's where the little a came about again capital A is the APO protein a that is on an HDL particle so there are distinctions between small APO a and uh capital A all right so if your liver if your Gene tell your liver protein macking apparatus to produce this apoa within the liver it binds to the APO B that's on a primordial LDL particle that's being produced in the liver so now some of your ldls APO little a binds to it and the liver just secretes them into your plasma so that's what an LP little a particle is