Paul Saladino· MD
if your CAC is zero if you have no plaque burden it it almost doesn't matter what your LDL is you know based on the studies we've looked at you know be insulin sensitive
Verbal pushback — no audited source on record.
74
Loading…
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if your CAC is zero if you have no plaque burden it it almost doesn't matter what your LDL is you know based on the studies we've looked at you know be insulin sensitive
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
so 45% of these people with FH with familiar hyperemia and elevated ldlc levels are not seeing CAC scores greater than zero and they're middle-age people this is not in young young familiar Hy cholesterol with people so you have you have incident you have studies like this then there's a variety of other studies where basically there's some really interesting ones where they're stratifying people's uh their LDL values into different categories and then they're basically seeing that in each category whether ldlc was 77 milligrams per deciliter or whether it was 190 milligrams per deciliter again LDL not total cholesterol if their CAC scores were zero they basically had a minimal risk of cardiovascular events and and uh they weren't really like they weren't really showing increased heart attacks and all this type of stuff with with even with these high ldlc levels
if your CAC is zero it doesn't mean your CAC will be zero for the rest of your life but I think that the chances that your CAC coronary coronary artery Cal score is going to remain zero for the majority of your life are pretty good if you're metabolically healthy
when you un so the process of the formation of plaque involves the movement of LDL particles generally modified LDL particles across the vascular wall that basically triggers an inflammatory response in the vascular wall and then you have the immune system come in and the macras start to interact with the LDL gobble it up and create these lipid loaded foam cells and now you start to get plaque formation
There's actually a recent study done with coronary artery calcium scores and in those people that had a coronary artery calcium score of zero, there was no connection, no relationship between levels of LDL cholesterol and cardiovascular disease.
If my calcium score is 0, my triglycerides are under 100 and my HDL is over 70, it is not reckless to decline pharmacological treatment.