Macrophages in individuals with monogenetic Familial Hypercholesterolemia have mutated LDL receptors, leading to upregulation of other receptors and impaired scavenger receptor function.

“the biggest takeaway even if you missed a lot of the technical things i just said is exactly this macrophages from those with familial hyper hypercholesterolemia and these species are physically different and those people have fh than in us and i think if it's anything to do with atherosclerosis you want to consider all the possible ways in which it could be a different process for those people who have fh and i think that that's what could possibly explain if we do not see this development of xanthomas why that really is a genetically different context”

“People with especially monogenic familial hypercholesterolemia which means familial hypercholesterolemia caused by one single gene mutation have very clear changes in the way that their immune cells function the the propensity of the maccrage is to take up LDL in the vessel wall is is is much higher”