HDL functionality, determined by its protein and phospholipid content, dictates its cardioprotective or detrimental effects on the artery wall, not its cholesterol cargo.

“whereas the HDL will not do that”

“we also know that some people have the type of hdls that don't perform those cardioprotective functions they actually perform bad functions to the artery wall and plaque and the heart”

“whether your hdls are doing those cardioprotective functions or they're doing bad things to your vasculature whatever they're doing has zero relationship to their cholesterol cargo meaning your HDL cholesterol level in the blood”

“the reason hdls have these either miraculous or disastrous properties comes down not to their lipid content certainly not their cholesterol content again but to their two things their protein content over 150 proteins have been found to be associated with various HDL particles and they perform an immense number of likely very necessary uh actions that need to go on in certain tissues where things may be going wrong we also know that the coat of an HDL apart from its proteins is virtually all phospholipids so the exact phos phol lipid concentration of an HDL surface has tremendous amount to what to do”

“the reason hdl's have these either miraculous or disastrous properties comes down not to their lipid content certainly not their cholesterol content but to their two things their protein content... and the exact phospholipid concentration of an HDL surface has tremendous amount to what to do”