Using antisense oligonucleotides to lower Lipoprotein(a) may cause a rebound increase in LDL-C as the knocked-out Lp(a) becomes LDL. — Whalespan
Using antisense oligonucleotides to lower Lipoprotein(a) may cause a rebound increase in LDL-C as the knocked-out Lp(a) becomes LDL.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“any concern that we're going to see a rebound increase in LDL with an antisense oligonucleotide so when you knock out LP little a all of those additional ldls that would have been LP little A's just become LPL so your APO B concentration stays the same even though you've shifted the distribution from between LP little a and LDL”