Hepatic lipase and endothelial lipase act on HDL particles, modifying their phospholipids and changing HDL size and protein composition.

“both of these lipases they're made in different places as their name suggests but both of them fundamentally chew on HDL specifically the phospholipids on HDL and result in modification of the phospholipid composition of the HCL particle in a way that does different things it certainly changes the sizes of the hdls and they contribute to this distribution of different sizes it changes the protein composition of the hdls in ways that we don't fully understand and almost certainly has other important biological effects that we don't fully understand”