In a study of individuals with very high LDL-C levels, there was no observed correlation between LDL-C values and plaque formation or CAC scores.

“relationship in this study between ldlc elevations and plaque formation they're not actually seeing any any relationship and there there's an interesting graph where they show like you can see the LDL values you can see the plaque scores and they're not correlated by any capacity some of the highest scores have zero plaque burden so that's the first thing with with these people with very high ldlc levels and we're not seeing this the the positive or the CAC scores greater than zero or we're not seeing elevations in plaque burden overall as the CCTA or the CAC scores which is that's a huge that's that's a huge uh thing to see because ideally if you have this if LDL is directly causitive in cardiovascular disease you would see you would assume a linear relationship or some type of relationship not necessarily always linear where the higher levels that you get the higher the higher the plaque Bur and you're not actually seeing that”

“I had an LDL of 500 once but it was just a onetime LDL and the last CAC that I've done was when I think it was probably five years ago I it was zero”