Lp(a) inheritance follows an autosomal dominant pattern, similar to monogenic disorders like familial hypercholesterolemia.

“part of the genetic heterogeneity among different people is the the apo lipoprotein a isoform size so uh people express uh different lpa isoforms some some are bigger than uh than the other and that that probably uh that well that actually plays an important part of the uh equation explaining why some people have a higher lp a little late than others”

“so the pattern of inheritance is true autosomal dominant uh pattern of inheritance so uh it's like any uh like for instance if you compare it with a monogenic disorder let's say familial hypercholesterolemia”

“because there's 2 000 different variants in the lpa region that are associated with high lpa so your father can have a high lpa because of a specific variant and your mother can have an lpa variant that lowers lpa but it depends on the combination of snips that you will ultimately get so it's not uh it's not as clear as any monogenic disorder even though it's a dominant mode of of inheritance”