Non-modifiable cardiovascular disease risk factors include age, specific genes like LPA, and strong family history not solely explained by lipids.

“I would say two of the most important um non-modifiable or really three would be obviously age um one particular Gene that we don't yet have the ability to fully modify its phenotype which is LP little a that we'll talk about and then of course there are other um very strong lines of family history that aren't necessarily transmitted through through lipids the way FH are uh the way the FH gene or sets of genes are in other words there there seem to be other polygenic causes here um that run very strongly in families”